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Weidong Hao

Professor
whao@bjmu.edu.cn
Xueyuan Road 38, Haidian District, Beijing, China
Peking University

Personal profile

Education:

September 1979--August 1984

School of Public Health, Beijing Medical University

Got Bachelor of Medicine degree in August 1984

August 1984--August 1987

Department of Toxicology, Beijing Medical University

Got Master of Medicine degree in August 1987

Research and Professional Experience:

August 1987--May 1990

Assistant, Department of Toxicology, Beijing Medical University

May 1990--May 1996

Lecturer, Department of Toxicology, Beijing Medical University

September 1990--September 1991 and April 1995-- April 1996

Visiting Scholar, Faculty of Pharmaceutical Sciences, Okayama University, Japan

June 1996--August 2001

Associate Professor and Vice Chairman, Department of Toxicology, Beijing Medical University

August 2001-- present

Professor and Chairman, Department of Toxicology,

Vice Dean, School of Public Health,

Peking University

Main Research Area:

Food Toxicology and Environmental Toxicology

Academic Positions:

Vice Chairman and Secretary General , Chinese Environmental Mutagen Society

Council Member，International Association of Environmental Mutagen and Genomic Societies

Member, Executive Committee of Asia Association of Environmental Mutagen Society

Member, Executive Council of Chinese Association of Preventive Medicine

Member, Executive Council of Chinese Toxicology Association

Vice Chairman, The Society of Environment and Health, Chinese Society of Environmental Science

Vice Chairman, The Society of Biological Chemical and Molecular Toxicology, Chinese Toxicology Association

Vice Chairman, The Society of Toxicological Alternatives and Translational Toxicology, Chinese Toxicology Association

Vice Chairman, The Society of Toxicity Testing and Alternative Methods, Chinese Environmental Mutagen Society

Associate Editor of Chinese Preventive Medicine (Chinese)

Associate Editor of Carcinogenesis, Teratogenesis & Mutagenesis (Chinese)

Main research directions

Food Toxicology and Environmental Toxicology

Representative scientific research projects

1. The National Key Research and Development Program of China, 2017YFC1600203, Safety evaluation of rare earth elements and additives in food based on toxic mechanism and health effect endpoints, 2018/01-2021/12, PI

2. National Natural Science Foundation of China, 82073586, Effect of 2-acetyl-4-tetrahydroxybutylimidazole on lymphocyte reduction and its mechanism, 2021/01-2024/12, PI

3. National Natural Science Foundation of China, 81773466, Study of reproductive toxicity by chlormequat chloride and its potential mechanism of impact testosterone synthesis through HPG axis, 2018/01-2021/12, PI

4. National Natural Science Foundation of China, 81473002, Study of embryotoxicity by chlormequat chloride and its potential mechanism through GH-IGF regulation axis, 2015/01-2018/12, PI

5. National Natural Science Foundation of China, 81273112, Effect of TAK1 mediated CD4(+) T cell activation on allergic contact dermatitis and auto immune hepatitis induced by trichloroethylene, 2013/01-2016/12, PI

6. National Natural Science Foundation of China, 30972501, Effect of signal transduction and epigenetic on neurodevelopmental toxicity by bisphenol A, 2010/01-2012/12, PI

7. National Natural Science Foundation of China, 30771821, Interaction and mechanism of developmental toxicity of phtoestrogens and synthetic chemicals, 2008/01-2010/12,PI

8. National Natural Science Foundation of China, 39600123, Molecular mechanism of gene mutation induced by sunlight and ultraviolet radiation, 1997/01-1999/12, PI

10 representative papers

1. Qianqian Xiao1, Xiaohong Hou, Chenping Kang, Linglu Xu, Lilan Yuan, Zhe Zhao, Qinghe Meng, Jianjun Jiang, Weidong Hao*, Chlorocholine chloride induced testosterone secretion inhibition mediated by endoplasmic reticulum stress in primary rat Leydig cells，Toxicology Letters, 2021, 356 :161–171

2. Qianqian Xiao, Xiaohong Hou, Chenping Kang, Bayindala Xiagedeer , Hong Hu , Qinghe Meng , Jianjun Jiang, Weidong Hao*, Effects of prenatal chlorocholine chloride exposure on pubertal development and reproduction of male offspring in rats, Toxicology Letters, 2021, 351 :28–36

3. Bayindala Xiagedeer, Xiaohong Hou, Qi Zhang, Hong Hu, Chenping Kang, Qianqian Xiao, WeidongHao*， Maternal chlormequat chloride exposure disrupts embryonic growth and produces postnatal adverse effects, Toxicology, 2020, 442:152534

4. Xiaohong Hou, Hong Hu, Bayindala Xiagedeer, Pengmin Wang, Chenping Kang, Qi Zhang, Qinghe Meng, Weidong Hao*. Effects of chlorocholine chloride on pubertal development and reproductive functions in male rats, Toxicology Letters, 2020, 319:1-10.

5. Bayindala Xiagedeer, Chenping Kang, Xiaohong Hou, Hong Hu, Qianqian Xiao, Weidong Hao*，Chlormequat chloride promotes rat embryonic growth and GH-IGF-1 axis, Toxicology，429:1-9

6. Yao Pan, Xiaohong Hou, Qinghe Meng , Xiaohua Yang , Lanqin Shang, XuetaoWei , Weidong Hao*，The critical role for TAK1 in trichloroethylene-induced contact hypersensitivity in vivo and in CD4+ T cell function alteration by trichloroethylene and its metabolites in vitro，Toxicology and Applied Pharmacology，2019，381:1-14

7. Xiaohong Hou, Dan Huang, Qinghe Meng, Qi Zhang, Lixia Jia, Siqi Wang, Zhiyuan Cheng, Shuang Wu, Lanqin Shang, Jianjun Jiang, Weidong Hao*, Pubertal chlorocholine chloride exposure inhibits testicular testosterone synthesis by down-regulating steroidogenic enzymes，Toxicology Letters, 2018, 288:17-24

8. Dan Huang，Shuang Wu，Xiaohong Hou，Lixia Jia，Qinghe Meng，Hongqian Chu，Jianjun Jiang，Lanqin Shang，Weidong Hao*，The Skeletal developmental toxicity of chlormequat chloride and its underlying mechanisms，Toxicology，2017, 381:1-9

9. Hongqian Chu，Jing Shang，Ming Jin，Yueyue Chen，Yao Pan，Yuan Li，Xi Tao，Zhiyuan Cheng，Qinghe Me，Qian Li，Guang Jia，Tong Zhu，Weidong Hao*，Xuetao Wei*，Comparison of lung damage in mice exposed to black carbon particles and 1,4-naphthoquinone coated black carbon particles，Science of the Total Environment, 2017, 580:572-581

10. Hongqian Chu，Jing Shang，Ming Jin，Qian Li，Yueyue Chen，Hongpeng Huang，Yuan Li，Yao Pan，Xi Tao，Zhiyuan Cheng，Qinghe Meng，Guang Jia，Tong Zhu，Xuetao Wei*，Weidong Hao*，Comparison of lung damage in mice exposed to black carbon particles and ozone-oxidized black carbon particles，Science of the Total Environment, 2016, 573:303-312